L-arginine is a “amino acid,” which is a chemical building block. It comes from food and is required for the body to produce proteins. Red meat, chicken, fish, and dairy items all contain L-arginine. It’s also possible to make it in a lab and utilize it as medication.
Congestive heart failure (CHF), chest discomfort, high blood pressure, high cholesterol, heart surgery, heart transplant recovery, heart attack, and coronary artery disease are among ailments that L-arginine is utilized for. L-arginine is also used to treat intermittent claudication (leg pain caused by blocked arteries), erectile dysfunction (ED), altitude sickness, nitrate tolerance, diabetes, diabetic nerve pain, cyclosporine toxicity, kidney disease, tuberculosis, critical illness, head and neck cancer, obesity, ovary disease (polycystic ovary syndrome), pressure ulcers, respiratory infections, and sickle cell disease.
Preventing the common cold, improving kidney function after a kidney transplant, high blood pressure during pregnancy (pre-eclampsia), improving athletic performance, boosting the immune system, and preventing inflammation and tissue death of the digestive tract in premature infants (necrotizing enterocolitis), as well as preventing the baby’s growth slowing within the uterus are all reasons why some people use L-arginine.
For a variety of illnesses, L-arginine is used with a number of over-the-counter and prescription drugs. For example, L-arginine is used in conjunction with ibuprofen to treat migraine headaches; with traditional chemotherapy drugs to treat breast cancer; with other amino acids to treat weight loss in people with AIDS; and with fish oil and other supplements to reduce infections, improve wound healing, and speed recovery after surgery.
L-arginine is applied to the skin to expedite wound healing, the repair of tiny anus tears, and to increase blood flow to chilly hands and feet, especially in diabetics. It’s also used as a cream for both men and women with sexual issues. Dental caries and hypersensitivity have both been treated with arginine.
Finally, arginine has been injected into the vein for recurrent pain in the legs caused by blocked arteries (intermittent claudication), reduced blood flow to the limbs (peripheral artery disease), growth hormone deficiency, disease caused by defective mitochondria (mitochondrial encephalomyopathies), chest pain caused by gastric problems, restenosis, kidney transplant, nutrition for the critically ill, metabolic acidosis, and increased blood pressure in the
What is the mechanism behind it?
Nitric oxide is formed when L-arginine is transformed in the body. Nitric oxide causes blood arteries to dilate, allowing more blood to flow through them. L-arginine also promotes the production of growth hormone, insulin, and other hormones and chemicals in the body.
Applications and efficacy
Possibly useful for:
- Pain in the chest (angina). In those with angina, using L-arginine appears to reduce symptoms, enhance exercise tolerance, and improve quality of life. L-arginine, on the other hand, does not appear to assist open blood arteries that are constricted in angina.
- Erectile dysfunction (ED) is a condition that affects men (ED). In males with ED, taking 5 grams of L-arginine daily by oral appears to enhance sexual performance. Lower dosages may not be as effective. However, preliminary research suggests that combining L-arginine with additional substances, such as maritime pine bark extract, may increase the efficacy of low-dose L-arginine for ED.
- Blood pressure that is too high. In healthy persons, those with high blood pressure, and people with slightly high blood pressure with or without diabetes, there is preliminary evidence that taking L-arginine by mouth will lower blood pressure.
- Premature newborns’ digestive tract inflammation and tissue death (necrotizing enterocolitis). In preterm newborns, adding L-arginine to formula appears to reduce digestive tract irritation. To avoid one case of digestive system irritation, arginine must be given to a total of 5 preterm newborns.
- Tolerance to nitrates. In those using nitroglycerin for chest discomfort, consuming L-arginine by oral appears to avoid nitrate tolerance (angina pectoris).
- Leg discomfort caused by a lack of blood flow (peripheral arterial disease). People with peripheral artery disease may benefit from taking L-arginine orally or intravenously (IV) for up to 8 weeks, according to research. In persons with peripheral vascular disease, however, long-term usage (up to 6 months) did not increase walking speed or distance.
- Improving post-surgery recovery. Taking L-arginine with ribonucleic acid (RNA) and eicosapentaenoic acid (EPA) before or after surgery appears to aid shorten recovery time, lower infection rates, and promote wound healing.
- Having high blood pressure when pregnant (pre-eclampsia). The majority of evidence suggests that L-arginine can help women with high blood pressure. In pregnant women, L-arginine may help to avoid this disease.
Possibly Ineffective for:
- Kidney disease is a condition that affects many people. The majority of early studies shows that taking L-arginine orally or intravenously (IV) does not enhance kidney function in the majority of persons with renal failure or illness. Taking L-arginine by oral, on the other hand, may enhance kidney function and reverse anemia in older patients with renal disease.
- A heart attack has occurred. L-arginine supplementation does not appear to help prevent heart attacks. It also does not appear to be effective in the treatment of a heart attack that has already occurred. In fact, some researchers believe that L-arginine may be detrimental to those who have recently had a heart attack. If you’ve recently suffered a heart attack, you shouldn’t take L-arginine.
- Tuberculosis. Adding arginine to regular TB treatment does not appear to alleviate symptoms or cure the illness.
- Healing of wounds L-arginine supplementation does not appear to promote wound healing.
There is insufficient evidence to rate the efficacy of
AIDS-related wasting is a kind of wasting that occurs as a result of the Taking L-arginine, hydroxymethylbutyrate (HMB), and glutamine by mouth for eight weeks appears to increase body weight and enhance immunological function in HIV/AIDS patients. In HIV-positive persons, however, taking L-arginine orally coupled with omega-3 fatty acids and a well-balanced dietary supplement for six months did not enhance body weight or fat mass, energy intake, or immunological function.
Altitude sickness. Early research suggests that L-arginine does not reduce altitude sickness.
Anal fissures. There is inconsistent evidence about that effects of L-arginine for treating anal fissures. Applying a topical gel containing L-arginine for at least 12 weeks might heal anal fissures in people who do not respond to traditional care. However, applying L-arginine to the skin does not seem to be better than surgery for anal fissures.
Breast cancer is a disease that affects women. Taking L-arginine before chemotherapy did not boost the response rate in patients with breast cancer, according to preliminary studies.
Heart failure is a serious condition. In those with heart failure, taking L-arginine by mouth, along with traditional therapy, appears to enhance kidney function. However, it is possible that it will not increase exercise capacity, quality of life, or blood circulation. L-arginine should not be used as a substitute for standard therapy.
the role of L-arginine in cardiac protection during CABG According to certain studies, delivering L-arginine intravenously (IV) to persons having CABG may be beneficial. Other study indicates that it is ineffective.
Blood vessels that are clogged (coronary artery disease). Early study shows that giving L-arginine intravenously (IV) before exercising can help persons with coronary artery disease improve blood vessel function. It does not, however, enhance blood flow to the heart.
Illness that is critical (trauma). In severely sick persons, ingesting L-arginine with glutamine, nucleotides, and omega-3 fatty acids by mouth improves recovery time, the need for breathing assistance, and the risk of infection, according to research. It does not, however, lessen the chance of mortality.
Loss of memory (dementia). L-arginine appears to help with memory decline associated with ageing, according to preliminary study.
Cavities. Early evidence shows that taking a sugarless mint with an arginine complex (CaviStat) for a year lowers the number of cavities in children’s molars when compared to sugarless mints without arginine.
Teeth that are sensitive. Early study reveals that brushing twice a day with a toothpaste containing arginine, calcium, and fluoride lowers tooth sensitivity.
Diabetes. People with diabetes who take L-arginine by mouth appear to have better blood sugar management. However, whether arginine helps patients with pre-diabetes from acquiring diabetes is unknown.
Diabetic foot ulcers are a common complication of diabetes. Early study suggests that daily application of L-arginine to the feet might enhance circulation in diabetics, which could help avoid diabetic foot ulcers. However, if a foot ulcer already exists, injecting L-arginine under the skin near the ulcer did not appear to speed up healing or reduce the likelihood of amputation in the future.
Nerve damage due to diabetes. Early research suggests that taking L-arginine daily for 3 months does not improve nerve damage related to diabetes.
Muscle problems in the esophagus. Early research suggests that taking L-arginine by mouth or as an infusion can reduces the number and intensity of chest pain attacks in people with chest pain that is not related to the heart.
A heart transplant is a procedure in which a person’ Early study reveals that taking L-arginine orally for six weeks improves walking distance and respiration in heart transplant recipients.
Infertility. The evidence regarding L-usefulness arginine’s in the treatment of infertility is mixed. According to preliminary studies, ingesting 16 grams of L-arginine daily enhances egg counts in women undergoing IVF. However, it does not appear to increase the number of pregnancies. According to other studies, consuming L-arginine did not increase the quality of sperm in men who are infertile for no apparent reason.
Kidney transplantation is a procedure in which a person receives The effects of L-arginine on persons who have had kidney transplants are controversial. It’s unknown if it’ll help.
Infections of the lungs. According to preliminary studies, ingesting L-arginine orally for 60 days avoids recurrence of respiratory infections in children.
Sickle-cell disease is a kind of sickle-cell illness. People with sickle cell disease who have high blood pressure in their lungs may benefit from taking L-arginine for 5 days, according to preliminary studies.
Stress. According to preliminary study, ingesting a combination of L-lysine and L-arginine for up to 10 days decreases tension and anxiety in both healthy and stressed adults.
Ovarian cancer is a kind of cancer that affects the (polycystic ovarian syndrome). In persons with polycystic ovarian syndrome, early study shows that taking N-acetyl-cysteine and L-arginine daily for 6 months can enhance menstruation function and reduce insulin resistance.
Poor growth of fetus during pregnancy. Early research suggests that taking L-arginine during pregnancy can increase the birthweight of babies who show poor growth while still in their mother’s womb. However, L-arginine does not seem to increase birthweight or reduce the risk of the baby dying if the baby has extremely poor growth while in the womb.
Mitochondrial encephalomyopathies (a group of disorders that lead to muscle and nervous system problems). There is some interest in using L-arginine to improve symptoms associated with MELAS (myoclonic epilepsy with lactic acidosis and stroke-like episodes) syndrome. Early research suggests that administering L-arginine intravenously (by IV) within one hour of stroke-like symptoms improves headaches, nausea, vomiting, blindness, and the appearance of bright spots in people with this condition.
Exercise performance. There is inconsistent evidence about the effects of L-arginine on exercise performance. Some evidence shows that taking 6 grams of L-arginine in a drink increases exercise time until becoming tired. Also taking arginine with grape seed extract appears to improve working ability in men and decreases their tiredness. However, taking arginine 6 grams once does not affect strength during exercise.
Ulcers caused by pressure. The combination of L-arginine with the pain reliever ibuprofen appears to be useful in the treatment of migraine headaches. Within 30 minutes, this combo may begin to act. However, because ibuprofen may treat migraine pain on its own, it’s difficult to say how much of the pain reduction is attributable to L-arginine.
Restricted blood flow (restenosis). Some research suggests that giving L-arginine during stent implantation followed by L-arginine supplementation by mouth for 2 weeks after stent implantation does not reduce the risk of restricted blood flow. However, other evidence suggests that administering L-arginine at the site of stent implantation may reduce artery wall thickening.
L-arginine Side effects
When taken correctly by mouth, as a shot, or applied to the skin for a brief period of time, L-arginine is POSSIBLY SAFE for most people. Abdominal discomfort, bloating, diarrhea, gout, blood irregularities, allergies, airway inflammation, asthma exacerbation, and low blood pressure are all possible adverse effects.
Special warnings and precautions
Pregnancy and breast-feeding: When taken by mouth for a brief period of time during pregnancy, L-arginine is POSSIBLY SAFE. Long-term use of L-arginine during pregnancy or breast-feeding is not well understood. To be on the safe side, avoid using it.
Children: When given to preterm newborns in suitable amounts, L-arginine is POSSIBLY SAFE. When used in excessive dosages, however, L-arginine is POSSIBLY UNSAFE. Too high doses can have significant consequences, including death in children.
Allergies or asthma: L-arginine might trigger an allergic reaction or exacerbate airway edema. If you have allergies or asthma and want to use L-arginine, proceed with caution.
Cirrhosis: People with cirrhosis should utilize L-arginine with care.
People who have guanidinoacetate methyltransferase deficiency are unable to convert arginine and other related compounds into creatine. These persons should avoid taking arginine to avoid problems related with this illness.
Herpes: It’s possible that L-arginine will aggravate herpes. It’s possible that L-arginine is required for the herpes virus to multiply.
L-arginine has been shown to reduce blood pressure. If you already have low blood pressure, this might be an issue.
Recent heart attack: L-arginine has been linked to an increased risk of mortality following a heart attack, particularly in elderly adults. Do not take L-arginine if you have recently suffered a heart attack.
Renal disease: When persons with kidney disease take L-arginine, their potassium levels rise. This has resulted in a potentially life-threatening irregular heartbeat in some circumstances.
L-arginine may alter blood pressure during surgery. It’s possible that it will affect blood pressure regulation during and after surgery. At least two weeks before a scheduled surgery, stop taking L-arginine.
The following doses have been studied in scientific research:
- 3-6 grams three times a day for up to one month for chest discomfort associated with coronary artery disease (angina pectoris).
- For inhibiting nitroglycerin’s ability to relieve discomfort in persons with chest pain caused by coronary artery disease (angina pectoris): Four times a day, take 700 mg.
- 5 grams per day for organic erectile dysfunction (ED). Lower dosages may not be as effective.
- 4-24 grams per day for 2-24 weeks if you have high blood pressure.
- 261 mg/kg administered to oral feedings daily for the first 28 days of life to avoid digestive system irritation in preterm newborns.
- For persons with peripheral arterial disease who are experiencing discomfort during walking: For up to 8 weeks, take 6 grams.
- 3 grams every day for 3 weeks to avoid excessive blood pressure during pregnancy. Starting from 14-32 weeks of pregnancy and continuing until birth, two bars of a medical food (Heart Bars) containing 6.6 grams of arginine and antioxidant vitamins should be consumed daily. For 10-12 weeks, take 4 grams of arginine (Bioarginina, Damor .