Dealing with the Problems Caused by Fillers

Dealing with the Problems Caused by Fillers

Beauty products containing fillers are among the most regularly used on the market.

The majority of the time, they are well tolerated, although any one of them may sometimes cause undesirable side effects.

As a general rule, unpleasant effects continue for as long as the filler is present in the skin, which implies that short-lived fillers have short-term side effects while permanent fillers may have long-term negative effects.

The primary objective is to prevent them from occurring; unfortunately, this is not always feasible to achieve.

The prevention of infections must be handled with the utmost care, and the injection method must be executed flawlessly.

Adverse effects are often treated with hyaluronidase or steroid injections, and in certain circumstances, 5-fluorouracil with allopurinol is taken orally to alleviate the symptoms.

Biopsy specimens are often subjected to histological testing, which aids in the identification of the filler responsible and the development of a customized treatment plan.


Fillers for volumetric rejuvenation of the face have gained appeal as a less invasive procedure for rejuvenation.

Complications, on the other hand, may arise.

Some side effects, such as erythema and edema, are temporary, but others, such as granulomas, may remain for a long period of time.

The treatment of complications is influenced by a number of variables.

The severity of the adverse effect: The majority of the initial side effects are minimal and will go away on their own within a few hours.

Side effects that are moderate in severity need therapy that is conservative in nature.

In the case of severe side effects, quick assistance may be required.

The duration of the unfavorable impact is often the same length of time as the duration of the desirable filler effects.

This is true for the vast majority of fillers.

Collagen, on the other hand, may cause them to persist.

There were stone-hard swellings on the skin of a middle-aged lady at every spot where she was injected with bovine collagen, including the testing area; these swellings refused to go away regardless of the therapies applied to them.

A granulomatous response to collagen injections occurs in roughly 6 percent of cases and responds to corticosteroid injections within a few weeks after the first injection.

When hyaluronic acid fillers were first introduced to the market, they were commonly associated with negative side effects, which were thought to be caused by the protein moiety that is present throughout the biosynthetic synthesis process.

These swellings were formerly prevalent at the injection site and quickly vanished with appropriate treatment; however, they are now quite unusual in patients. Lumping of a filler results in lumps and bumps that must be surgically removed in most cases.

Permanent fillers are associated with long-term negative effects.

Inflammatory filler reactions are classified as reversible or temporary (caused by collagen and hyaluronic acid); late and long-term (caused by poly-L-lactic acid (PLLA), calcium hydroxylapatite, alginate, and dextranomer beads in hyaluronic acid); and delayed and permanent (caused by poly-L-lactic acid (PLLA), calcium hydroxylapatite, alginate, and dextranomer beads (caused by vaseline, paraffin, silicone oil, hydroxyethyl methacrylate fragments, polymethylmethacrylate beads, polyacrylamide, and polyalkylimide gels).

Most people believe that temporary fillers have little adverse effects; nevertheless, the incidence of side effects is equivalent to that of long-term and permanent fillers, but their length is shorter and hence they are less significant.


Bruising, swelling, and erythema are all common early adverse effects of injections of foreign substances; nevertheless, they are a natural physiological response to the injection and may frequently be alleviated by chilling the injected region.

Pain may be decreased by using a gradual injection technique and administering local anesthetics in modest amounts.

Using arnica, aloe Vera, or vitamin K lotions is reported to help lessen the appearance of bruises.

 When a patient has previously been exposed to an allergen, allergies might manifest itself within hours after exposure.

Whenever an improper filler is injected superficially or in the incorrect area, lumps and bumps appear.

These may arise quickly or develop over time as a result of the material clumping together as a result of muscular activation.

When an artery occlusion occurs as a result of an unintentional intravascular injection or compression by the filler volume, vascular impairment becomes apparent within a day.

A blunt cannula, rather than a sharp injection needle, prevents accidental intravascular injection from occurring during the procedure.

This is especially harmful for the glabella, inner corner of the eye, and ala nasi, and it has been observed to induce skin necrosis and even blindness in certain cases in these areas. The majority of instances were caused by autologous fat (n=47), hyaluronic acid (n=23), and collagen (n=8), with all other substances used as fillers accounting for less than 5 percent of all cases. Fifty-nine instances were reported from South Korea, where the information was gathered from the country’s top retinal institutes and hospitals.

Whenever blanching is seen during the injection, the procedure must be halted immediately and recommenced

Dealing with the Problems Caused by Fillers
Dealing with the Problems Caused by Fillers

Hyaluronidase is injected around the vasculature in order to avoid the negative effects of hyaluronic acid filler from manifesting themselves.

Additional supportive interventions include aggressive massage, warm compresses, and the use of topical nitroglycerin.

Late complications are those that manifest themselves after about 2-6 weeks.

Lateral allergic responses, chronic inflammation and infection, granulomas, filler migration, loss of function, telangiectasia, and hypertrophic scars are some of the manifestations of this condition. 

A thorough medical history may reveal the presence of an allergy.

In order to prevent infection, the injection site must be carefully cleansed and defatted before to the injection, and the injection must not be performed via makeup to avoid contamination.

Antibiotics should be administered as soon as possible to treat the infection, which normally responds swiftly.

Granuloma creation is random, however it is influenced by the substance utilized in its production. Particulate material, especially permanent fillers, but also poly-L-lactic acid (PLLA), the particles of which have a crystalloid structure, is prone to eliciting a macrophagic response.

Granulomas are more likely to form if the surface-to-volume ratio of the filler particles is low and the particles have sharp edges, as seen in the figure. Granulomas are seldom caused by homogenous fillers.

Good-quality hyaluronic acid fillers are almost completely absent of this effect, as is collagen.

 Silicone oil causes a somewhat distinct response known as siliconoma with lymphocytic infiltrates, which is caused by the presence of lymphocytes.

Permanent fillers based on acrylate gels have the appearance of being homogeneous, although they are in reality particle.

Late responses are those that manifest themselves six weeks after the injection of the filler material.

They are believed to be caused mostly by bacterial biofilms, but this has been vigorously contested.

They have the potential to cause granulomas as well as so-called cold abscesses.

Because biofilms are mostly bacterial in origin, steroid injections should not be used to treat or prevent them.

Delayed adverse effects might manifest months or years after the filler has been injected, and the patient is often unable to recall which filler was used or if additional fillers were also injected.

Nonphysical injectors are often unaware of the potential adverse effects of the fillers they employ, and they fail to adhere to basic clinical standards like as sanitation and the use of gloves while performing their procedures.


The majority of undesirable effects are not associated with a specific filler.

They may occur as a consequence of volume augmentation or as a result of technical errors such as incorrect indication, incorrect insertion location, incorrect injection needle, and infection as a result of contaminated ice or drinking water.

Radiolabeled leukocyte scintigraphy is used to distinguish infection-related nodules and granulomas from other types of nodules and granulomas.

Inflammatory and immune-mediated deleterious consequences often manifest themselves late in the course of the disease. The most often reported adverse effects include persistent edema, granulomas, sarcoid-like responses, and panniculitis.

Systemic granulomatous illness, autoimmune disorders, and acute hypersensitivity responses are all very infrequent in the general population.

It is possible that manipulation near to an injection site will result in infection even years after the filler has been placed.

Fat derived from a person’s own body

Excellent outcomes can only be achieved by adhering strictly to important concepts such as sterile procedures and low-volume injections over many layers of tissue.

Adverse consequences are quite uncommon. Although early adoption of surgical methods by persons who do not have a thorough knowledge of the underlying ideas and techniques might be beneficial, doing so prematurely can be fatal.

Furthermore, any physician who performs surgery on a patient must be aware of the possibility of problems and be ready to handle them correctly if they do arise.

Fat lifespan is determined by the procedures used in handling and preparing the fat. Insufficient fat viability results in an inadequate outcome.

In this case, it must be seen as an additional difficulty.

A patient with Romberg’s syndrome, on the other hand, had negative cosmetic outcomes as a consequence of considerable weight gain as a result of corticosteroids, oral contraception, and a change in lifestyle.

Approximately 140 mL of filler was injected to achieve a goal volume of 100 mL in 880 instances, and the results were stable for 3-4 months after the procedure. Following the treatment, there were no radiological concerns detected during mammography.

Only 3 percent of the patients had fat necrosis, which was considered a small number. 

One incidence of infection at the harvest site, six cases of infection at the injection site, and one case of intraoperative pneumothorax were among the serious consequences.

There have also been reports of abscess development, life-threatening infection, and persistent deformity after surgery.
Recently, an analysis of published literature in the English-language literature revealed that 98 cases of vision change were caused by filler injections, with 47 cases being caused by autologous fat injection.

 One patient developed necrosis of her left eye within two days of receiving the injection and died within four days of receiving the injection.

Neurological complications following fat injection included two patients who experienced unilateral loss of vision following fat injection in the glabella, two patients who experienced sudden loss of vision, aphasia, and hemiparesis, and one patient who experienced sensorimotor hemiparesis following infarction of the middle cerebral artery.

A well-vascularized tissue mass, a quick local rise in pressure in the injected tissue, and fragmentation of parenchyma are three of the preconditions that predispose to intravascular fat embolism.

We believe that bits of fatty tissue are transported to and from the ocular and cerebral arteries by reversed flow through branches of the carotid arteries that originate in facial veins.

Fat embolism complications might manifest itself either immediately after the fat injection or after a period of latency.

 It is possible that it will stay subclinical and so will not be detected, or that the clinical symptoms will be misconstrued.

Fat injections must be conducted carefully and with the least amount of power feasible in order to reduce the possibility of such a serious consequence.

 Following fat injections into the face, it may be beneficial to have a routine funduscopic checkup.

Collagen from humans

Autologous human collagen is well tolerated, both when obtained from cultured fibroblasts and when used as an injectable dermis substitute from autologous human skin.

The use of human allogeneic collagen was discovered to cause acute-to-subacute inflammatory responses, but no major long-term negative effects were observed to have occurred. The aesthetic impact lasts for 4 to 7 months after application.

Collagens derived from nonhuman sources

Nonhuman collagens, notably bovine collagen, are alien proteins that may cause allergic reactions and granulomas in susceptible individuals.

 Porcine collagen, on the other hand, is more tolerable.
Side effects are usually transient until all collagen has been destroyed, although one patient had stone-hard granulomas that refused to go away after repeated treatments over a period of more than a decade.

The majority of granulomas are palisaded around amorphous eosinophilic material that is thought to be bovine collagen in origin. 

The presence of structureless deposits, the absence of birefringence, and mild gray-violet staining with Masson’s trichrome stain are all characteristics of this condition.

It has not been determined if the collagenase injection will be effective. 

Temporary granulomas occurred at the injection site in around 4-6 percent of the participants studied.

Preliminary testing and double testing were advised before treatment, and in both instances granulomas were discovered to have occurred.

Collagen fillers are now being used less often, and as a consequence, it is believed that side effects will be few.

Hyaluronic acid is a kind of sugar that is found in the body’s fluids.

Hyaluronic acid (HA) is found in all animal species and is responsible for the formation of connective tissue. Hyaluronans are not exclusive to any one species; nonetheless, they are connected to proteins that are distinct to certain species.

Good preparations are (nearly) completely devoid of non-essential proteins.

Even though they have a low proclivity to cause granulomas, they are associated with a range of transitory side effects, including rare granulomas and infection.

At the moment, there are roughly 200 HA preparations available on the market.

High-quality brands with a low incidence of difficulties are favored since their complication rate is much lower. This helps to avoid unfavorable side effects.

Cheap items that have not been thoroughly evaluated should not be utilized at all.

the most extensively used filler in the world right now.

Depending on the molecule size, cross-linking process, and injection site, it may last for around 6 months.

They vary in terms of molecular size, protein content, chemical bonding, fluidity, whether or not they are monophasic or biphasic, the amount of injection pain they cause, and the length of time that they last.

A proper preparation does not clump, since this might lead to the formation of granulomas in the body. 

They were relatively uncommon during the beginning of the nonanimal-derived synthetic HAs (NASHAs) era, but they are now very rare, with the exception of new, inexpensive, untested goods, which are especially prevalent when purchased online over the internet.

During the early stages of the usage of HA fillers, it was considered that the responses were caused by hypersensitivity.

Erythematous multiform rashes and systemic anaphylactoid responses are very unusual adverse effects that may develop following intra-articular injection of HA using natural HA that has a lesser sensitizing capacity than the synthetic HA used in the study.

Side effects caused by the chemical are generally short-lived and may be remedied almost immediately by injecting hyaluronidase into the affected area.

The dosage is determined by the individual medicine being used, as well as by the amount of HA employed and the degree of cross-linking achieved.

Tags: body care, self-care, skin care

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